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Research Group Cellular Neurophysiology

The Work Group Cellular Neurophysiology (Group Leader: Dr. Moritz Frech) is concerned with the generation and characterization of model systems of neurodegenerative diseases based on hiPSC technology. The focus is on patient-specific neural model systems, which are generated by hiPSCs from skin fibroblasts of NPC1 patients.

These neuronal cell systems are characterized among other things by functional electrophysiological methods, such as the patch clamp technique, but also by molecular biological methods such as qRT-PCR, Western Blot or immunocytochemical staining. The analyses serve to gain a deeper understanding of the pathogenic processes in the affected cells and thus to develop therapeutic approaches that positively influence the course of the disease.

Research Group Cellular Neurophysiology

Dr. Moritz Frech (Group Leader)
Alexandra Jürs (MD Student)
Maik Liedtke (PhD Student)
Michael Rabenstein (PhD Student)
Christin Völkner (PhD Student)
Nico Murr (MSc Student)